EPAFinal Rule

Pesticide Tolerance; Exemptions, Petitions, Revocations, etc.: SpCas9 Protein

AgricultureHealthcareEnvironment

Summary

The EPA is proposing to set safety limits (or possibly exempt from limits) for a protein called SpCas9, which is used in genetic engineering to modify crops. The agency is asking the public to comment on whether this protein is safe enough to allow in food before making a final decision.

Key Points

  • 1SpCas9 is a protein tool used in gene-editing technology (CRISPR) to modify plants and crops
  • 2The EPA is determining what safety rules should apply to foods containing this protein or made with this editing technique
  • 3The public has until February 18, 2026 to submit comments on whether they think this protein is safe
  • 4This decision could affect what genetically modified foods are allowed to be grown and sold in the United States
  • 5The regulation addresses pesticide tolerance, meaning the EPA is deciding how much of this substance (if any) can be present in food

Key Dates

Published

December 16, 2025

Comment Deadline

February 18, 2026

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This summary is for informational purposes only. It may not capture all nuances of the regulation. Always refer to the official text for authoritative information.

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